The emergence of new concerns at national, regional and global levels on the sustainability of security in the Middle East and North Africa (MENA) has been followed by development of new paradigms for tackling instability and insecurity at home, as well as, at our immediate neighborhood and at international arena. As for the Middle East, it seems that NATO has joined the regional countries to address pressing issues such as home security, human security, marine security, energy security, environmental security, terrorism; WMDs, missile defense, etc. as issues of common concern. However, despite its enterprises for the Mediterranean, the ‘İstanbul Cooperation Initiative (ICI)’, and its substantive reliance on its public diplomacy apparatus to convince the regional countries to accept this approach and facilitate NATO’s incursion in management of regional security, there are hard evidences and certain facts indicating that as far as this approach is not inclusive and grass-root, it will be doomed to failure.