A real-life “Game of Thrones” is developing in the wider region surrounding the Black Sea and beyond, extending to the Middle East, Southeast Europe, and Mediterranean regions, through multileveled approaches to security and strategy. What ignited separatist movements in the regions of Ukraine in 2014 was just the starting point of a larger change that will eventually affect the balance of power and the future role of states in the area and neighborhood. Developments in the region have reached a pivotal point; one that requires a total change of objectives and strategies. A shift in the power balance between leading and peripheral states is therefore beginning to manifest itself. New alliances will be created and old ones will be reshaped or forgotten.