In consideration of the general instability in the Middle East – the bloody Syrian civil war and its mounting refugee crisis, the overthrow of the Muslim Brotherhood in Egypt, the emergence of ISIL and ongoing fighting in Iraq, and the war in Yemen – the author argues that the geographical map of the region based on the 1916 Sykes-Picot Agreement is disintegrating. Furthermore, the author argues that the region’s turmoil has to some extent had a spillover effect on the three non-Arab states – Turkey, Iran, and Israel, which further adds troubles to the region. While Israel is largely an outlier, the author posits that Turkey, Iran, and Saudi Arabia will be embroiled in the “increasingly bitter contest for dominance of the Muslim Middle East.”